Innovation in Therapeutic Interventions

Innovation in Therapeutic Interventions

  • Recently, new topical drugs such as substance P and IGF-1 were tested on diabetic animals to accelerate re-epithelialization. Successful outcomes were obtained with these new drugs. 
  • Corneal epithelial barrier function was shown to improve with topical aldose reductase inhibitors. 
  • Amino-guanidine has beneficial effects in corneal epithelial defects, by improving attachment between the epithelial cells and basement membrane of the cornea. 
  • In additional to these new drugs, amniotic membrane transplantation is used to treat persistent corneal epithelial defects. Amniotic membrane (AM) can function in the eye as a basement membrane substitute or as a temporary graft. It has anti-inflammatory and anti-scarring effects and contains growth factors that promote epithelial (layer of cells on surface of cornea) wound healing on the surface of the eye.