Characterisation of DES Progression in People Living with Diabetes

Characterisation of DES Progression in People Living with Diabetes

Severe cases of DES in people living with diabetes leads to visual impairment (disturbances to the corneal layer can alter how light enters the eye), corneal scarring and ulcers (without sufficient protective tear film which contains anti-bacterial compounds, wounds on the cornea will be slow to heal and susceptible to infection), leading to secondary bacterial infections that can spread. The synergistic effect of corneal infection and diabetes accelerates corneal lesions, which irreversibly change the ocular surface and induce visual impairment. Tear film dysfunction not only leads to the occurrence of dry eye but simultaneously aggravates the ocular surface, which induces a corneal epithelial defect and keratopathy, more information can be found in the Diabetes-related Keratopathy section.